@extends("base.html") @require(htmlbase, view, pluginbase) @def content():

Fold Change

Calculate fold change between two experimental groups
Martin A. Fitzpatrick

Introduction

Fold change is a useful measure to describe changes from an initial to final value, for example between control and test subjects in an experiment.

Quick start

Select source data input and enter the experimental comparison on the experimental toolbar (control:test classification from the source data). The resulting values will be shown in the output table.

The plugin can auto-generate a minima value for your dataset, using half the smallest value detected. This allows fold changes to be calculated for data where the initial value was zero (which will otherwise give a divide-by-zero error).

Notes

There are a number of ways to calculate fold change. This plugin represents downward values as a negative fold, rather than a proportion < 1. For example a value falling from 2 to 1 is given as a -2 fold change. This is more practical for representing the change visually on linear coloured scales.

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